Principles of Biochemical Toxicology, Fourth Edition

Author: John A. Timbrell

Publisher: Informa Health Care

ISBN: 0849373026

Category: Medical

Page: 464

View: 8126

DOWNLOAD NOW »

This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards. Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching. New to the Fourth Edition: reorganized sections that cover basic principles followed by sections on different types of toxicity extensive use of examples throughout and numerous explanatory diagrams new material on risk assessment, export systems, oxidative stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic acid, bone marrow (benzene), heart (adriamycin), blood (primaquine), biomarkers, cytochrome P450 and other enzymes, receptor mediated effects, endocrine disruption, ethanol, botox, arsenic, and more questions with answers for each chapter for review and self-checking expanded and updated chapter bibliographies

Molecular and Biochemical Toxicology

Author: Robert C. Smart,Ernest Hodgson

Publisher: John Wiley & Sons

ISBN: 1118679725

Category: Science

Page: 944

View: 4502

DOWNLOAD NOW »

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition. Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include: New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.

Introduction to Toxicology, Third Edition

Author: John Timbrell

Publisher: CRC Press

ISBN: 9781420055993

Category: Medical

Page: 215

View: 5501

DOWNLOAD NOW »

Since the publication of the first edition of Introduction to Toxicology , toxicology has become a more mature science, the number of undergraduate and postgraduate courses has increased and thus the need for a regularly updated introductory text has become more pressing. This third edition caters for this need in a clear and easy-to-read style, featuring: * Up-to-the-minute information * Relevant toxicological examples that reinforce principles * End-of-chapter essay questions * New and redrawn illustrations * Glossary of terms * Extensively revised bibliography The fundamental principles of absorption, distribution, metabolism and excretion are described in the introductory chapters, as are the types of exposure and response. In subsequent chapters these are clarified with the use of carefully chosen examples. Among the topics considered are the potential adverse effects of drugs, pesticides, food additives and industrial chemicals.

Introduction to toxicology

Author: John A. Timbrell

Publisher: N.A

ISBN: 9780850664263

Category: Medical

Page: 155

View: 9505

DOWNLOAD NOW »

Since the publication of the first edition of Introduction to Toxicology, toxicology has become a more mature science, the number of undergraduate and postgraduate courses has increased and thus the need for a regularly updated introductory text has become more pressing. This third edition caters for this need in a clear and easy-to-read style, featuring: * Up-to-the-minute information* Relevant toxicological examples that reinforce principles* End-of-chapter essay questions* New and redrawn illustrations* Glossary of terms* Extensively revised bibliography The fundamental principles of absorption, distribution, metabolism and excretion are described in the introductory chapters, as are the types of exposure and response. In subsequent chapters these are clarified with the use of carefully chosen examples. Among the topics considered are the potential adverse effects of drugs, pesticides, food additives and industrial chemicals.

Principles of Biochemical Toxicology, Third Edition

Author: John Timbrell

Publisher: CRC Press

ISBN: 0748407367

Category: Medical

Page: 404

View: 3645

DOWNLOAD NOW »

Research into the biochemical basis of toxicology has expanded rapidly over recent years, amidst concerns over the adverse effects of drugs, environmental pollution and occupational hazards. Following on from the acclaimed first two editions of Principles of Biochemical Toxicology, John Timbrell has expanded the text to include: summary sections questions and model answers thoroughly revised artwork These features, plus the new easy-to-read format will make biochemical toxicology more accessible to undergraduates and postgraduates coming across the subject for the first time, particularly when undertaking self-directed study. This comprehensive textbook provides a thorough explanation of dose-response relationships; disposition and metabolism; toxic responses to foreign compounds, and detailed examples to illustrate mechanisms of toxicity. There is also an expanded and updated bibliography, directing the reader to further reading if required. Students and lecturers will find the clear and concise approach, which established this book as the leading textbook in its field, an essential aid to learning and teaching.

Bioanalytical Tools in Water Quality Assessment

Author: Beate Escher,Frederic Leusch

Publisher: IWA Publishing

ISBN: 1843393689

Category: Science

Page: 253

View: 1278

DOWNLOAD NOW »

Bioanalytical Tools in Water Quality Assessment reviews the application of bioanalytical tools for assessment of water quality including surveillance monitoring. The types of water included range from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Bioanalytical Tools in Water Quality Assessment not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. Bioanalytical tools in Water Quality Assessment can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists, and toxicologists.

Principles of Ecotoxicology, Fourth Edition

Author: C.H. Walker,R.M. Sibly,S.P. Hopkin,D.B. Peakall

Publisher: CRC Press

ISBN: 1466502606

Category: Science

Page: 386

View: 7574

DOWNLOAD NOW »

Cutting across traditional subject boundaries, Principles of Ecotoxicology, Fourth Edition gives readers an integrated view of ecotoxicology, from molecules to ecosystems. This new edition of a bestselling textbook continues to emphasize principles rather than practice, providing the interdisciplinary perspective and grounding required for research. Organized into three sections, the book first describes the molecular structures, properties, and environmental fate of pollutants. It then deals with the effects of pollutants on living organisms at the molecular, cellular, and individual levels. Moving into population biology and population genetics, the third part of the book addresses a question of great interest to ecologists: What effects do pollutants have at the levels of population, community, and the whole ecosystem? The book also looks at how ecotoxicology is used in the biomonitoring of environmental pollution, the investigation of pollution problems, the conducting of field trials, the study of the development of resistance, and the growing area of environmental risk assessments. Throughout, examples and case studies illustrate the principles. This updated fourth edition includes new material on nanoparticle pollution, bioaccumulation, biomarkers, and chemical warfare in nature, as well as a new chapter on the future directions of ecotoxicology. A concise textbook that will also appeal to practicing ecotoxicologists, it provides a solid basis for understanding what happens to chemicals in the real world, where they go, how they ultimately degrade, and how they affect the individuals and populations that encounter them. What’s New in This Edition Revised and updated material throughout A chapter on future directions of ecotoxicology New material on nanoparticle pollution and chemical warfare in nature Expanded coverage of bioaccumulation, biomarkers, and risk assessment for affected populations More case studies, many from the United States Discussion of neurotoxic and behavioral effects of pollutants Recent research on the decline of vultures and effects of neonicotinoids on bees Organic Pollutants: An Ecotoxicological Perspective, Second Edition (CRC Press, 2008), a companion volume to this book, covers the mechanistic aspects of ecotoxicology in more depth.

Anorganische Chemie

Prinzipien von Struktur und Reaktivität

Author: James Huheey,Ellen Keiter,Richard Keiter

Publisher: Walter de Gruyter GmbH & Co KG

ISBN: 3110307952

Category: Science

Page: 1340

View: 9423

DOWNLOAD NOW »

This modern textbook stands out from other standard textbooks. The framework for the learning units is based on fundamental principles of inorganic chemistry, such as symmetry, coordination, and periodicity. Specific examples of chemical reactions are presented to exemplify and demonstrate these principles. Numerous new illustrations, a new layout, and large numbers of exercises following each chapter round out this new edition.

Fundamentals of Environmental and Toxicological Chemistry

Sustainable Science, Fourth Edition

Author: Stanley E. Manahan

Publisher: CRC Press

ISBN: 1466553162

Category: Science

Page: 614

View: 9166

DOWNLOAD NOW »

Fundamentals of Environmental and Toxicological Chemistry: Sustainable Science, Fourth Edition covers university-level environmental chemistry, with toxicological chemistry integrated throughout the book. This new edition of a bestseller provides an updated text with an increased emphasis on sustainability and green chemistry. It is organized based on the five spheres of Earth’s environment: (1) the hydrosphere (water), (2) the atmosphere (air), (3) the geosphere (solid Earth), (4) the biosphere (life), and (5) the anthrosphere (the part of the environment made and used by humans). The first chapter defines environmental chemistry and each of the five environmental spheres. The second chapter presents the basics of toxicological chemistry and its relationship to environmental chemistry. Subsequent chapters are grouped by sphere, beginning with the hydrosphere and its environmental chemistry, water pollution, sustainability, and water as nature’s most renewable resource. Chapters then describe the atmosphere, its structure and importance for protecting life on Earth, air pollutants, and the sustainability of atmospheric quality. The author explains the nature of the geosphere and discusses soil for growing food as well as geosphere sustainability. He also describes the biosphere and its sustainability. The final sphere described is the anthrosphere. The text explains human influence on the environment, including climate, pollution in and by the anthrosphere, and means of sustaining this sphere. It also discusses renewable, nonpolluting energy and introduces workplace monitoring. For readers needing additional basic chemistry background, the book includes two chapters on general chemistry and organic chemistry. This updated edition includes three new chapters, new examples and figures, and many new homework problems.

Biological Monitoring

Heutige und Kunftige Moglichkeiten in der Arbeits- und Umweltmedizin

Author: Jurgen Angerer

Publisher: John Wiley & Sons

ISBN: 3527621210

Category: Science

Page: 218

View: 4963

DOWNLOAD NOW »

Auf Einladung der Deutschen Forschungsgemeinschaft (DFG) fand am 9. und 10. März 2000 ein Rundgespräch über heutige und künftige Möglichkeiten des Biomonitoring in Arbeits- und Umweltmedizin statt. Das Biomonitoring hat nicht zuletzt durch die unmittelbare Umsetzung der Arbeitsergebnisse der Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe in geltendes Recht durch die deutsche Arbeitsschutzgesetzgebung in den letzten dreißig Jahren in Deutschland ein hohes Niveau erreicht. Das vorliegende Buch führt die Expertise verschiedener Fachdisziplinen von der Toxikologie, Arbeitsmedizin, Immunologie und Humangenetik bis hin zur Analytik und Epidemiologie zusammen. Hierbei wird die diagnostische Aussagekraft von zytogenetischen Parametern sowie von biochemischen und biologischen Effektmarkern für die Prävention von schadstoffbedingter Erkrankungen ausführlich erörtert. Das geführte Rundgespräch hat somit einen ersten Gedankenaustausch ermöglicht, aus dem sich künftige Forschung entwickeln soll, um die führende Rolle Deutschlands auf diesem wichtigen und sich dynamisch entwickelnden Forschungsgebiet zu halten.

An Introduction to Environmental Toxicology Fourth Edition

Author: Michael Dong

Publisher: Createspace Independent Publishing Platform

ISBN: 9781979904513

Category:

Page: 528

View: 4555

DOWNLOAD NOW »

The core content difference between this Fourth and the Third Edition is minimal. In addition to the correction of the typos found in the Third Edition, this Fourth Edition has made minor refinements but updated substantially the status and the discussion of numerous contemporary issues covered in this book. In particular, this Fourth Edition has highlighted a number of recent public health and regulatory concerns, including the global concerns with the recent pandemics of Zika as well as Ebola and the U.S. Food and Drug Administration's ban on trans fats in all American processed foods by 2018. Moreover, it has updated the five persistent organic pollutants that the Stockholm Convention has added to its action list since the publication of this book's Third Edition in 2014. As three more update examples, this book is now current with the latest estimate data available concerning the annual amounts of pesticide active ingredients used in the United States and worldwide. It is now consistent with the International Agency for Research on Cancer's latest determinations made on the human carcinogenicity potential of the biological, physical, and chemical agents that the agency has analyzed. Furthermore, it is now up to date with the chemical elements included in the current periodic table. As with the earlier editions, this Fourth Edition offers an introductory text on the scope and principles for as well as the relevant topics of environmental toxicology. To this end, the book is organized into 23 chapters under four parts (sections) as listed below. PART I. TOXICOLOGIC CONCEPTS AND ENVIRONMENTAL ISSUES: (1) Scope and Principles for/of Environmental Toxicology; (2) Environmental Changes and Environmental Health; (3) Environmental Pollution and Regulatory Agencies; (4) Occurrence and Types of Environmental Toxicants; and (5) Fate and Transport of Toxicants in the Environment. PART II. BIOACCUMULATION AND BIODISPOSITION OF TOXICANTS: (6) Bioaccumulation of Persistent Environmental Toxicants; (7) Uptake, Distribution, and Excretion of Toxicants; (8) Metabolism/Biotransformation of Xenobiotics; (9) Adverse Action/Toxic Response; and (10) Factors and Conditions Affecting Toxicity. PART III. NATURE AND EFFECTS OF ENVIRONMENTAL TOXICANTS: (11) Air Pollutants - I: Inorganic Gases; (12) Air Pollutants - II: Particulate Matter; (13) Volatile Organic Compounds; (14) Toxic and Radioactive Metals; (15) Pesticides and Pesticide Residues; (16) Persistent Toxic Substances; and (17) Biological and Underrated Physical Toxic Agents. PART IV. SPECIAL TOPICS, ISSUES, CONSIDERATIONS, AND FOCI: (18) Environmental Mutagenesis/Carcinogenesis; (19) Reproductive Toxicity and Endocrine Disruption; (20) Occupational Toxicology/Workplace Hazards; (21) Food Toxicants and Toxic Household Substances; (22) Human Health Aspects of Ecotoxicology; and (23) Environmental Health Risk Assessment.

Fundamentals of Ecotoxicology, Second Edition

Author: Michael C. Newman,Michael A. Unger

Publisher: CRC Press

ISBN: 9781566705981

Category: Science

Page: 480

View: 9975

DOWNLOAD NOW »

Completely revised and updated, Fundamentals of Ecotoxicology, Second Edition presents a treatment of ecotoxicology ranging from molecular to global perspectives. The authors focus first on lower levels of organization and then extend their discussion to include landscape, regional, and biospheric topics, imparting a perspective as broad as the the problems facing practicing professionals. See what's new in this edition: A comprehensive chapter on the nature, transport, and fate of major classes of contaminants in terrestrial, freshwater, and marine systems Side bars containing vignettes by leaders in the field let you benefit from the experience of diverse practitioners in the field An appendix covering European environmental regulations The authors detail key contaminants of concern, explore their fate and cycling in the biosphere, and discuss bioaccumulation and the effects of contaminants at increasing levels of ecological organization. They cover regulatory aspects of the field in separate chapters that address the technical issues of risk assessment and discuss key U.S. and European legislation in the appendices. Complete with study questions, a detailed glossary, and vignettes by various experts exploring special topics in ecotoxicology, Fundamentals of Ecotoxicology, Second Edition is an ideal introductory textbook for both undergraduate- and graduate-level courses, as well as a valuable reference for professionals.

BASICS Neurochirurgie

Author: Stephan Dützmann

Publisher: "Elsevier,Urban&FischerVerlag"

ISBN: 3437292404

Category: Medical

Page: 136

View: 5148

DOWNLOAD NOW »

Gut – besser - BASICS Verloren im Dickicht der Überinformation? Schluss mit dem Stress: Mit der BASICS-Reihe gewinnen Sie den Überblick! GUT: umfassender Einblick - von den Grundlagen bildgebender Verfahren über Tumoren, spinale und zerebrovaskuläre Neurochirurgie bis zur Epilepsiechirurgie, mit neuem Kapitel „komplexe Wirbelsäulenchirurgie“ BESSER: praxisorientiert mit klinischen Fallbeispielen BASICS: jedes Thema strukturiert auf je einer Doppelseite dargestellt. Ansprechend farblich unterlegt, angenehm zu lesen und mit vielen ansprechenden, neuen Bildern aus der Praxis Das Beste: geschrieben von jungen Ärzten mit viel praktischer und didaktischer Erfahrung. So wird Neurochirurgie verständlich, ohne zu sehr ins Detail zu gehen. Ideal zum Einarbeiten ins Thema!

Innere Medizin...in 5 Tagen

Author: Wolfram Karges,Sascha Al Dahouk

Publisher: Springer-Verlag

ISBN: 3642207820

Category: Medical

Page: 416

View: 5954

DOWNLOAD NOW »

5 Tage für innere Ruhe - Strukturiert und konzentriert bekommen Sie hier die prüfungsrelevante Innere Medizin in 5 Tagen. Für alle, die sich kurz vor knapp auf das "Hammerexamen" vorbereiten und während des PJs kaum Zeit haben ist dieses Buch "der Hammer". Die Inhalte sind nach ihrer Häufigkeit in den IMPP-Fragen gewichtet. So können Sie sicher sein, nicht stundenlang Exoten zu lernen, die dann doch nie geprüft werden. Die Texte sind stichpunktartig geschrieben, sinnvolle Tabellen und Hinweise auf Prüfungsfallen und Verwechslungsgefahren ergänzen die Fakten. Platz für eigene Notizen bietet die Randspalte, so können Sie auch ganz spezielle Inhalte für die mündliche Prüfung festhalten. Und natürlich können Sie die Lerneinheiten auch auf eine längere Zeit verteilen. Kürzer und kompakter geht es für die Prüfung nun wirklich nicht.

Toxicology of Inhaled Materials

General Principles of Inhalation Toxicology

Author: H.P. Witschi,J.D. Brain

Publisher: Springer Science & Business Media

ISBN: 3642695213

Category: Medical

Page: 556

View: 5459

DOWNLOAD NOW »

This book deals with the methods and scientific basis of inhalation toxicology. It describes devices and facilities needed to expose animals to inhaled particles and gases as well as approaches to estimating or measuring the fraction of the inhaled material that is retained in the respiratory tract. The book then reviews the evergrowing repertoire of techniques that can be used to measure the responses elicited by the exposure. Quantitative and qualitative anatomical, physiological, and biochemical strategies are discussed in detail. We believe that the toxicology of inhaled materials is an important and timely topic for several'reasons. During the past decade, morbidity and mortality attributable to cardiovascular disease have significantly decreased. Progress in combatting cancer, the second most important cause of death, has been slower, and lung cancer actually became the leading cause of death in men and the second leading cause of cancer death in women. In addition, the incidence of non-neo plastic respiratory diseases such as emphysema, fibrosis, and chronic bronchitis has increased the past decade. In the United States, the National Institutes of Health (NIH) has recently reported that chronic obstructive pulmonary disease affects nearly 10 miliion persons and accounts for 59,000 deaths yearly; indeed, it ranks as the fifth leading cause of death. Because the incidence is increasing, the NIH estimates that it may become the nation's fourth or even third leading cause of death by the year 2000.

Last Minute Pharmakologie

Author: Claudia Dellas

Publisher: "Elsevier,Urban&FischerVerlag"

ISBN: 3437298003

Category: Medical

Page: 224

View: 690

DOWNLOAD NOW »

Last Minute – die optimale Prüfungsvorbereitung kurz vor der Prüfung! Sie haben das Fach Pharmakologie bereits einmal gelernt und wollen das Wichtigste in letzter Minute vor der Prüfung wiederholen? Genau das bietet Ihnen die Last Minute Reihe: nur die Fakten, die zum Bestehen der Prüfung notwendig sind Farbkodierung: Gewichtung nach IMPP-Häufigkeit eingeteilt in schnell schaffbare Lerneinheiten mit Online-Prüfungstraining: typische Fragen und Antworten. Von Studenten dringend empfohlen: "Damit schaffst Du den relevanten Stoff in minimaler Zeit." "Das ist eine wichtige und abwechslungsreiche Alternative zum reinen Fragen-Kreuzen." "Super ist das vorgegebene Gerüst zum strukturierten und effektiven Lernen." So gehen Sie sicher und selbstbewusst ins Hammerexamen!