Concepts in Bioinformatics and Genomics

Author: Alison McCurdy

Publisher: Oxford University Press, USA

ISBN: 9780199936991

Category: Bioinformatics

Page: 560

View: 5613


Concepts in Bioinformatics and Genomics takes a conceptual approach to its subject, balancing biology, mathematics, and programming, while highlighting relevant real-world applications. Topics are developed from the fundamentals up like in an introductory textbook. This is a comprehensive bookfor students enrolled in their first course in bioinformatics. A compelling case study gene, the TP53 gene, a human tumor suppressor with strong clinical applications, runs throughout, engaging students with a continuously relevant example.The textbook thoroughly describes basic principles of probability as they lead up to the concept of expectation value (E-value) and its use in sequence alignment programs. Concepts in Bioinformatics and Genomics also describes, from a mathematical perspective, the development of the Hidden MarkovModel and how it can be used to align sequences in multiple sequence alignment programs. Finally, it introduces students to programming exercises directly related to bioinformatics problems. These thought-provoking exercises stretch the students' imaginations and learning, giving them a deeperunderstanding of software programs, molecular biology, basic probability, and program-coding methodology underpinning the discipline. They will have the tools necessary to compute biological data.

Angewandte Bioinformatik

Eine Einführung

Author: Paul M. Selzer,Richard J. Marhöfer,Oliver Koch

Publisher: Springer-Verlag

ISBN: 3662541351

Category: Science

Page: 184

View: 2200


Für Studierende und Wissenschaftler der Lebenswissenschaften schafft dieses Buch einen schnellen, strukturierten Zugang zur Angewandten Bioinformatik ohne Programmierkenntnisse oder tiefgehende Informatikkenntnisse vorauszusetzen. Es bietet eine Einführung in die tägliche Anwendung der vielfältigen bioinformatischen Werkzeuge und gibt einen ersten Überblick über das sehr komplexe Fachgebiet. Die Kontrolle des vermittelten Stoffs wird durch Übungsbeispiele mit Lösungen gewährleistet. Ein Glossar der zugrundeliegenden Fachtermini sowie ein ausführliches Sachverzeichnis runden das Buch ab. Für die 2. Auflage wurde das Werk umfassend aktualisiert.

Graph-Theoretic Concepts in Computer Science

31st International Workshop, WG 2005, Metz, France, June 23-25, 2005, Revised Selected Papers

Author: Dieter Kratsch

Publisher: Springer Science & Business Media

ISBN: 9783540310006

Category: Computers

Page: 470

View: 5437


This book constitutes the thoroughly refereed post-proceedings of the 31st International Workshop on Graph-Theoretic Concepts in Computer Science, WG 2005, held in Metz, France in June 2005. The 38 revised full papers presented together with 2 invited papers were carefully selected from 125 submissions. The papers provide a wealth of new results for various classes of graphs, graph computations, graph algorithms, and graph-theoretical applications in various fields. The workshop aims at uniting theory and practice by demonstrating how graph-theoretic concepts can be applied to various areas in Computer Science, or by extracting new problems from applications. The goal is to present recent research results and to identify and explore directions of future research.

Bioinformatics in the Post-genomic Era

The Role of Biophysics

Author: Ivan Y. Torshin

Publisher: Nova Publishers

ISBN: 9781600210488

Category: Science

Page: 255

View: 6094


Biomedicine is one of the most important fields for the prospective applications of the information from human genome studies. However, there are many 'white spots' in the present-day understanding of the biomedical implications of this information. Given that at least half of the proteins in the established sequence of the human genome have no annotation whatsoever and that the sequence similarity searches are not likely to produce any, definite research strategies to analyse the functions of these unknown proteins as well as other enigmatic aspects of the human genome are being elaborated. The elaboration of the logistics of these research strategies, of the relevant computational methodologies as well as the general management of the informational complexity of the biological systems belong to the main tasks for the post-genomic bioinformatics. This volume concentrates on the role of the biophysical studies and biophysical concepts that can assist the endeavour.

Essays in Bioinformatics

Author: David S. Moss,Sibila Jelaska,Sándor Pongor

Publisher: IOS Press

ISBN: 1586035398

Category: Medical

Page: 251

View: 9238


Consists of chapters summarizing the fundamental concepts of bioinformatics, based on the topics presented at a course held in Dubrovnik, Croatia, in 2003. The second part of this book contains application papers submitted by the students after the course.

Concepts and Techniques in Genomics and Proteomics

Author: N Saraswathy,P Ramalingam

Publisher: Elsevier

ISBN: 1908818050

Category: Science

Page: 268

View: 6141


Concepts and techniques in genomics and proteomics covers the important concepts of high-throughput modern techniques used in the genomics and proteomics field. Each technique is explained with its underlying concepts, and simple line diagrams and flow charts are included to aid understanding and memory. A summary of key points precedes each chapter within the book, followed by detailed description in the subsections. Each subsection concludes with suggested relevant original references. Provides definitions for key concepts Case studies are included to illustrate ideas Important points to remember are noted

Essential Concepts in Molecular Pathology

Author: William B. Coleman,Gregory J. Tsongalis

Publisher: Academic Press

ISBN: 9780080922188

Category: Science

Page: 462

View: 8991


This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. Offers an essential introduction to molecular genetics and the "molecular" aspects of human disease Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology. "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine Each chapter ends with Key Summary Points and Suggested Readings

Bioinformatics: Genomics and Proteomics

Author: Ruchi Singh

Publisher: Vikas Publishing House

ISBN: 9325978555

Category: Technology & Engineering

Page: N.A

View: 8889


This is an innovative textbook for undergraduates as well as postgraduates offering basic knowledge of biology. Its aim is to provide state-of-the-art information about this developing science that has the potential to replace existing biological approaches to study genes and proteins. The chapters are explained in a concise yet detailed manner, including ample cross-references, references to literature and databases, tables and illustrations. The book's sound approach to this intricately complex field makes it an exceptional resource for further exploration into biochemistry, molecular biology, genomics and drug designing fields. Abundant learning features make this book the ideal teaching and learning tool. KEY FEATURES • Illustrations to bolster understanding of complex biochemical relations • Tables for quick access to precise data • Extensive end-of-chapter exercises and references • The most basic details furnished for those who are new to biology • User-friendly, Internet-based bioinformatics tools that allow researchers to extract information from databases and analyze it • Analysis of one software tool discussed in each chapter step-by-step from entering the input till interpretation of the results This is an in-depth textbook written for the biologist who wants a thorough understanding of the popular bioinformatics programs and molecular databases currently in use. It provides a broad, application-oriented overview of this technology.

Evolutionary Genomics and Systems Biology

Author: Gustavo Caetano-Anollés

Publisher: John Wiley & Sons

ISBN: 1118210719

Category: Science

Page: 480

View: 6883


A comprehensive, authoritative look at an emergent area inpost-genomic science, Evolutionary genomics is an up-and-coming,complex field that attempts to explain the biocomplexity of theliving world. Evolutionary Genomics and Systems Biology isthe first full-length book to blend established and emergingconcepts in bioinformatics, evolution, genomics, and structuralbiology, with the integrative views of network and systems biology. Three key aspects of evolutionary genomics and systems biologyare covered in clear detail: the study of genomic history, i.e.,understanding organismal evolution at the genomic level; the studyof macromolecular complements, which encompasses the evolution ofthe protein and RNA machinery that propels life; and theevolutionary and dynamic study of wiringdiagrams—macromolecular components in interaction—inthe context of genomic complements. The book also features: A solid, comprehensive treatment of phylogenomics, theevolution of genomes, and the evolution of biological networks,within the framework of systems biology A special section on RNA biology—translation, evolutionof structure, and micro RNA and regulation of gene expression Chapters on the mapping of genotypes to phenotypes, the role ofinformation in biology, protein architecture and biologicalfunction, chromosomal rearrangements, and biological networks anddisease Contributions by leading authorities on each topic Evolutionary Genomics and Systems Biology is an idealbook for students and professionals in genomics, bioinformatics,evolution, structural biology, complexity, origins of life,systematic biology, and organismal diversity, as well as thoseindividuals interested in aspects of biological sciences as theyinterface with chemistry, physics, and computer science andengineering.


The Machine Learning Approach

Author: Pierre Baldi,Professor Pierre Baldi,Søren Brunak,Francis Bach

Publisher: MIT Press

ISBN: 9780262025065

Category: Computers

Page: 452

View: 6119


Pierre Baldi and Soren Brunak present the key machine learning approaches and apply them to the computational problems encountered in the analysis of biological data. The book is aimed at two types of researchers and students. First are the biologists and biochemists who need to understand new data-driven algorithms, such as neural networks and hidden Markov models, in the context of biological sequences and their molecular structure and function. Second are those with a primary background in physics, mathematics, statistics, or computer science who need to know more about specific applications in molecular biology.

Concepts in Biotechnology

History, Science and Business

Author: Klaus Buchholz,John Collins

Publisher: John Wiley & Sons

ISBN: 3527691111

Category: Science

Page: 498

View: 4244


Adopting a unique approach, this novel textbook integrates science and business for an inside view on the biotech industry. Peering behind the scenes, it provides a thorough analysis of the foundations of the present day industry for students and professionals alike: its history, its tools and processes, its markets and products. The authors, themselves close witnesses of the emergence of modern biotechnology from its very beginnings in the 1980s, clearly separate facts from fiction, looking behind the exaggerated claims made by start-up companies trying to attract investors. Essential reading for every student and junior researcher looking for a career in the biotech sector.

Algorithms in Bioinformatics

4th International Workshop, WABI 2004, Bergen, Norway, September 17-21, 2004, Proceedings

Author: Inge Jonassen,Junhyong Kim

Publisher: Springer Science & Business Media

ISBN: 3540230181

Category: Science

Page: 477

View: 4238


This book constitutes the refereed proceedings of the 4th International Workshop on Algorithms in Bioinformatics, WABI 2004, held in Bergen, Norway, in September 2004. The 39 revised full papers presented were carefully reviewed and selected from 117 submissions. Among the topics addressed are all current issues of algorithms in bioinformatics, such as exact and approximate algorithms for genomics, genetics, sequence analysis, gene and signal recognition, alignment, molecular evolution, phylogenetics, structure determination or prediction, gene expression and gene networks, proteomics, functional genomics, and drug design.

Data Mining in Bioinformatics

Author: Jason T. L. Wang,Mohammed J. Zaki,Hannu Toivonen,Dennis Shasha

Publisher: Springer Science & Business Media

ISBN: 1846280591

Category: Computers

Page: 340

View: 9841


Written especially for computer scientists, all necessary biology is explained. Presents new techniques on gene expression data mining, gene mapping for disease detection, and phylogenetic knowledge discovery.

Computational Intelligence in Bioinformatics

Author: Ajith Abraham

Publisher: Springer Science & Business Media

ISBN: 3540768025

Category: Computers

Page: 326

View: 3799


Bioinformatics involve the creation and advancement of algorithms using techniques including computational intelligence, applied mathematics and statistics, informatics, and biochemistry to solve biological problems usually on the molecular level. This book deals with the application of computational intelligence in bioinformatics. Addressing the various issues of bioinformatics using different computational intelligence approaches is the novelty of this edited volume.

Algorithms in Bioinformatics

14th International Workshop, WABI 2014, Wroclaw, Poland, September 8-10, 2014. Proceedings

Author: Dan Brown,Burkhard Morgenstern

Publisher: Springer

ISBN: 3662447533

Category: Computers

Page: 369

View: 9584


This book constitutes the refereed proceedings of the 14th International Workshop on Algorithms in Bioinformatics, WABI 2014, held in Wroclaw, Poland, in September 2014. WABI 2014 was one of seven conferences that were organized as part of ALGO 2014. WABI is an annual conference series on all aspects of algorithms and data structure in molecular biology, genomics and phylogeny data analysis. The 26 full papers presented together with a short abstract were carefully reviewed and selected from 61 submissions. The selected papers cover a wide range of topics from sequence and genome analysis through phylogeny reconstruction and networks to mass spectrometry data analysis.

Advances in Bioinformatics and Computational Biology

Brazilian Symposium on Bioinformatics, BSB 2005, Sao Leopoldo, Brazil, July 27-29, 2005, Proceedings

Author: Joao Carlos Setubal,Sergio Verjovski-Almeida

Publisher: Springer Science & Business Media

ISBN: 3540280081

Category: Computers

Page: 258

View: 8896


This book constitutes the refereed proceedings of the Brazilian Symposium on Bioinformatics, BSB 2005, held in Sao Leopoldo, Brazil in July 2005. The 15 revised full papers and 10 revised extended abstracts presented together with 3 invited papers were carefully reviewed and selected from 55 submissions. The papers address a broad range of current topics in computational biology and bioinformatics.

Bayesian Modeling in Bioinformatics

Author: Dipak K. Dey,Samiran Ghosh,Bani K. Mallick

Publisher: CRC Press

ISBN: 9781420070187

Category: Mathematics

Page: 466

View: 700


Bayesian Modeling in Bioinformatics discusses the development and application of Bayesian statistical methods for the analysis of high-throughput bioinformatics data arising from problems in molecular and structural biology and disease-related medical research, such as cancer. It presents a broad overview of statistical inference, clustering, and classification problems in two main high-throughput platforms: microarray gene expression and phylogenic analysis. The book explores Bayesian techniques and models for detecting differentially expressed genes, classifying differential gene expression, and identifying biomarkers. It develops novel Bayesian nonparametric approaches for bioinformatics problems, measurement error and survival models for cDNA microarrays, a Bayesian hidden Markov modeling approach for CGH array data, Bayesian approaches for phylogenic analysis, sparsity priors for protein-protein interaction predictions, and Bayesian networks for gene expression data. The text also describes applications of mode-oriented stochastic search algorithms, in vitro to in vivo factor profiling, proportional hazards regression using Bayesian kernel machines, and QTL mapping. Focusing on design, statistical inference, and data analysis from a Bayesian perspective, this volume explores statistical challenges in bioinformatics data analysis and modeling and offers solutions to these problems. It encourages readers to draw on the evolving technologies and promote statistical development in this area of bioinformatics.

Issues in Genetic Research: 2011 Edition

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464966044

Category: Medical

Page: 591

View: 7779


Issues in Genetic Research / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Genetic Research. The editors have built Issues in Genetic Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetic Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Genetic Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Advances in Bioinformatics and Computational Biology

Third Brazilian Symposium on Bioinformatics, BSB 2008, Sao Paulo, Brazil, August 28-30, 2008, Proceedings

Author: Ana L.C. Bazzan

Publisher: Springer Science & Business Media

ISBN: 3540855564

Category: Computers

Page: 181

View: 6268


The Brazilian Symposium on Bioinformatics (BSB) 2008 was held at Santo Andr´e(Sao ˜ Paulo), Brazil, August 28–30,2008. BSB 2008 was the third sym- sium in the BSB series, although BSB was preceded by the Brazilian Workshop on Bioinformatics(WOB). This previous event had three consecutiveeditions in 2002 (Gramado, Rio Grande do Sul), 2003 (Maca´ e, Rio de Janeiro), and 2004 (Bras´ ?lia, Distrito Federal). The change from workshop to symposium re?ects the increasing quality and interest behind this meeting. For BSB 2008, we had 41 submissions: 32 full papers and 9 extended - stracts, submitted to two tracks: the main track on Computational Biology and Bioinformatics, and the track Applications of Agent Technologies and Mult- gent Systems to Computational Biology.The currentproceedings contain 14 full papers and5 extended abstractsthat wereaccepted. Thesepapers andabstracts were carefully refereed and selected by an international Program Committee of 35 members, with the help of 13 additional reviewers. We believe that this v- ume represents a ?ne contribution to current research in computational biology and bioinformatics, as well as in molecular biology.

Algorithms in Bioinformatics

6th International Workshop, WABI 2006, Zurich, Switzerland, September 11-13, 2006, Proceedings

Author: Philipp Bücher,Bernard M.E. Moret

Publisher: Springer Science & Business Media

ISBN: 3540395830

Category: Computers

Page: 402

View: 7671


Here are the refereed proceedings of the 6th International Workshop on Algorithms in Bioinformatics, WABI 2006, held in the course of the ALGO 2006 conference meetings. The book presents 36 revised full papers addressing all current issues of algorithms in bioinformatics, from mathematical tools to experimental studies of approximation algorithms and reports on significant computational analyses. For the first time, coverage extends to machine-learning approaches along with combinatorial optimization.