Concepts in Bioinformatics and Genomics

Author: Alison McCurdy

Publisher: Oxford University Press, USA

ISBN: 9780199936991

Category: Bioinformatics

Page: 560

View: 9794

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Concepts in Bioinformatics and Genomics takes a conceptual approach to its subject, balancing biology, mathematics, and programming, while highlighting relevant real-world applications. Topics are developed from the fundamentals up like in an introductory textbook. This is a comprehensive bookfor students enrolled in their first course in bioinformatics. A compelling case study gene, the TP53 gene, a human tumor suppressor with strong clinical applications, runs throughout, engaging students with a continuously relevant example.The textbook thoroughly describes basic principles of probability as they lead up to the concept of expectation value (E-value) and its use in sequence alignment programs. Concepts in Bioinformatics and Genomics also describes, from a mathematical perspective, the development of the Hidden MarkovModel and how it can be used to align sequences in multiple sequence alignment programs. Finally, it introduces students to programming exercises directly related to bioinformatics problems. These thought-provoking exercises stretch the students' imaginations and learning, giving them a deeperunderstanding of software programs, molecular biology, basic probability, and program-coding methodology underpinning the discipline. They will have the tools necessary to compute biological data.

Angewandte Bioinformatik

Eine Einführung

Author: Paul M. Selzer,Richard J. Marhöfer,Oliver Koch

Publisher: Springer-Verlag

ISBN: 3662541351

Category: Science

Page: 184

View: 2554

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Für Studierende und Wissenschaftler der Lebenswissenschaften schafft dieses Buch einen schnellen, strukturierten Zugang zur Angewandten Bioinformatik ohne Programmierkenntnisse oder tiefgehende Informatikkenntnisse vorauszusetzen. Es bietet eine Einführung in die tägliche Anwendung der vielfältigen bioinformatischen Werkzeuge und gibt einen ersten Überblick über das sehr komplexe Fachgebiet. Die Kontrolle des vermittelten Stoffs wird durch Übungsbeispiele mit Lösungen gewährleistet. Ein Glossar der zugrundeliegenden Fachtermini sowie ein ausführliches Sachverzeichnis runden das Buch ab. Für die 2. Auflage wurde das Werk umfassend aktualisiert.

Genetik für Dummies

Author: Tara Rodden Robinson

Publisher: John Wiley & Sons

ISBN: 3527811478

Category: Science

Page: 400

View: 6999

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Die Genetik ist eine der Naturwissenschaften, deren Wissen am schnellsten wächst und deren Erkenntnisse ständig in Bewegung und in der Diskussion sind. "Genetik für Dummies" erklärt, was überhaupt hinter diesem spannenden Thema steckt. Die Autorin Tara Rodden Robinson erklärt die Grundlagen der Vererbungslehre wie die Mendelschen Regeln, wie Zellen aufgebaut sind und sie sich teilen. Sie zeigt, wie die DNA aufgebaut ist, wie sie kopiert und richtig in Proteine übersetzt wird. Außerdem geht sie auf die Bedeutung der Genetik in der Humanmedizin ein, wie Genmutationen und Erbkrankheiten entstehen. Sie erläutert, was beim Klonen passiert und was sich überhaupt hinter dem Begriff Gentechnik verbirgt. Auch die heißen Themen wie Stammzellentherapie und der Einsatz der Genetik in der Rechtsmedizin werden behandelt.

Evolutionary Genomics and Systems Biology

Author: Gustavo Caetano-Anollés

Publisher: John Wiley & Sons

ISBN: 1118210719

Category: Science

Page: 480

View: 7615

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A comprehensive, authoritative look at an emergent area inpost-genomic science, Evolutionary genomics is an up-and-coming,complex field that attempts to explain the biocomplexity of theliving world. Evolutionary Genomics and Systems Biology isthe first full-length book to blend established and emergingconcepts in bioinformatics, evolution, genomics, and structuralbiology, with the integrative views of network and systems biology. Three key aspects of evolutionary genomics and systems biologyare covered in clear detail: the study of genomic history, i.e.,understanding organismal evolution at the genomic level; the studyof macromolecular complements, which encompasses the evolution ofthe protein and RNA machinery that propels life; and theevolutionary and dynamic study of wiringdiagrams—macromolecular components in interaction—inthe context of genomic complements. The book also features: A solid, comprehensive treatment of phylogenomics, theevolution of genomes, and the evolution of biological networks,within the framework of systems biology A special section on RNA biology—translation, evolutionof structure, and micro RNA and regulation of gene expression Chapters on the mapping of genotypes to phenotypes, the role ofinformation in biology, protein architecture and biologicalfunction, chromosomal rearrangements, and biological networks anddisease Contributions by leading authorities on each topic Evolutionary Genomics and Systems Biology is an idealbook for students and professionals in genomics, bioinformatics,evolution, structural biology, complexity, origins of life,systematic biology, and organismal diversity, as well as thoseindividuals interested in aspects of biological sciences as theyinterface with chemistry, physics, and computer science andengineering.

Bioinformatik

Ein Leitfaden für Naturwissenschaftler

Author: Andrea Hansen

Publisher: Springer-Verlag

ISBN: 3034878559

Category: Science

Page: 156

View: 800

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Wie berechnet man multiple Alignments? Wie nutzt man eine Datenbank, um die mühsam im Labor ermittelten Sequenzen effektiv zu analysieren? Und welche Datenbank ist überhaupt am besten geeignet? Locker und leicht verständlich geschrieben führt dieser Leitfaden in die Geheimnisse der Bioinformatik ein, ohne dass man als Naturwissenschaftler gleich Informatik im Nebenfach belegt haben muss. Schwerpunkt des Buches sind die Grundlagen und verschiedenen Möglichkeiten der Sequenzanalyse. Das Buch beginnt mit einer Einführung in die wichtigen Sequenzdatendatenbanken am NCBI und EMBL sowie in die wachsende Zahl der Motivdatenbanken. Anschließend werden die einfachsten Methoden des paarweisen Sequenzvergleiches in globalen und lokalen Alignments beschrieben sowie die gängigsten heuristischen Verfahren der Datenbanksuche (FASTA und BLAST). Multiple Alignments, Substitutionsmatrizen und die Berechnung phylogenetischer Bäume werden dem Leser nahe gebracht. Neu hinzugekommen sind auch Erläuterungen der Prinzipien der Genomanalyse und der gängigsten Algorithmen zur Genvorhersage. Zu jeder Methode werden Online-Tools im Internet oder freie Software angegeben. Der Leser wird so in die Lage versetzt, die beschriebenen Methoden selbstständig nachzuvollziehen. Die Autorin selbst ist Molekularbiologin und in der Bioinformatik-Branche tätig. Als ehemalige Betreuerin eines Bioinformatik-Kurses weiss sie aus eigener Erfahrung, auf welche Informationen es ankommt, um schnell und zielorientiert zu den gewünschten Ergebnissen zu gelangen. Das Buch richtet sich in erster Linie an Anwender und Einsteiger in die Bioinformatik. Angesprochen sind vor allem Studenten und Forscher aus allen Gebieten der Naturwissenschaften, die sich in Studium oder Beruf mit der Sequenzanalyse auseinandersetzen müssen. Gleichzeitig ist dieses Buch auch ein Leitfaden für all diejenigen, die die aufgeführten Methoden zwar regelmässig benutzen, aber noch nie die Zeit gefunden haben, sich mit den Grundlagen auseinanderzusetzen.

Bioinformatics

A Concept-Based Introduction

Author: Venkatarajan Mathura,Pandjassarame Kangueane

Publisher: Springer Science & Business Media

ISBN: 0387848703

Category: Science

Page: 190

View: 6812

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Bioinformatics is an evolving field that is gaining popularity due to genomics, proteomics and other high-throughput biological methods. The function of bioinformatic scientists includes biological data storage, retrieval and in silico analysis of the results from large-scale experiments. This requires a grasp of knowledge mining algorithms, a thorough understanding of biological knowledge base, and the logical relationship of entities that describe a process or the system. Bioinformatics researchers are required to be trained in multidisciplinary fields of biology, mathematics and computer science. Currently the requirements are satisfied by ad hoc researchers who have specific skills in biology or mathematics/computer science. But the learning curve is steep and the time required to communicate using domain specific terms is becoming a major bottle neck in scientific productivity. This workbook provides hands-on experience which has been lacking for qualified bioinformatics researchers.

Bioinformatics

Principles, Basic Internet Applications

Author: Hassan A. Sadek

Publisher: Trafford Publishing

ISBN: 1412025176

Category: Science

Page: 100

View: 6739

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This text is a resource for academics and students who want to develop collaborative learning environments. Dr. Hassan cites recent progress in bioinformatics databases that gives a hands-on, in-depth understanding that goes beyond rote memorization. Students interested in acquiring a working knowledge of the fundamentals of bioinformatics can easily become overwhelmed by the vast abundance of information on the subject. Bioinformatics: Principles and Basic Internet Applications has been specially designed to provide a concise yet comprehensive introduction to the field of bioinformatics. This brief, practical, tightly organized text shows you how to perform the biological applications. It is the only guide you need for bioinformatics every time.

Bioinformatics

Author: Dilip K Arora,Randy Berka,Gautam B. Singh

Publisher: Elsevier

ISBN: 9780080463704

Category: Computers

Page: 350

View: 2130

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The advances in genomic technologies, such as microarrays and high throughput sequencing, have expanded the realm of possibilities for capturing data and analyzing it using automated computer driven bioinformatics tools. With the completion of the sequencing of genomes of human and several model organisms, a quest for scientific discoveries being fueled by integrative and multidimensional techniques in mathematics and computational sciences. In this volume, leading researchers and experts have provided an overview of significant concepts from biological, mathematical, and computational perspectives. It provides a high level view of fungal genomic data integration and annotation, classification of proteins and identification of vaccine targets, identification of secretome or secreted proteins in fungal genomes, as well as tools for analyzing microarray expression profiles. Provides a survey of theoretical underpinnings on the technological tools and applications Discusses the tools utilized for the annotation of fungal genomes and addresses issues related to automated annotation generation in a high throughput biotechnology environment Describes the applications of the concepts and methodologies presented throughout the book

BIOINFORMATICS: A PRACTICAL GUIDE TO THE ANALYSIS OF GENES AND PROTEINS, 3RD ED

Author: Andreas D. Baxevanis,Francis B. F. Ouellette

Publisher: N.A

ISBN: 9788126521920

Category: Bioinformatics

Page: 560

View: 462

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Market_Desc: This new edition is aimed at advanced undergraduate and graduate school students taking an introductory bioinformatics courses, as well as professionals in genomics, molecular biology, biochemistry, biophysics, and computational biology. According to a Science review of a previous edition, this book should be in the personal library of any biologist who uses the Internet for the analysis of DNA and protein sequence data and is invaluable to beginners and seasoned researchers alike. Special Features: · Complete, expert coverage of key principles as well as the state-of-the-art in bioinformatics· All new chapters on: Genome Annotation, Genomic Databases, Predictive Methods Using RNA Sequences, Protein Structure Prediction, and Protein-Protein Interactions· Fully redesigned, appealing design with full color throughout and larger trim size· Reorganization of chapters into five main sections following a clear, logical sequence· Inclusion of greatly expanded and more rigorous problem sets· Special boxes highlighting experimental strategies and limitations· More diagrams and flowcharts to reinforce the main text· Enhanced use of real examples· written by the top scientists in the field of bioinformatics, [this book] is the perfect choice for every molecular biology laboratory --Quarterly Review of Biology (2/e)· No background in computer science or mathematics assumed About The Book: This fully revised third edition to an already classic resource provides readers with a practical guide covering the full scope of key concepts in bioinformatics, from databases to predictive and comparative algorithms. With a new full-color, enlarged page design, this edition offers the most readable, up-to-date, and thorough introduction to the field for biologists. All new features include special boxes, enhanced use of real examples, and expanded problem sets with answers provided on the book's dedicated website (www.wiley.com/bioinformatics). A glossary and appendix of sample file formats rounds out the book's reader-friendly, 'hands-on' treatment.The chapters have been reorganized into a more logical flow, with five main sections and a concluding section offering a primer on the use of Perl. Following the editors' introduction and perspective on why bioinformatics is important.

Bioinformatics for Biologists

Author: Pavel Pevzner,Ron Shamir

Publisher: Cambridge University Press

ISBN: 1139501615

Category: Science

Page: N.A

View: 7849

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The computational education of biologists is changing to prepare students for facing the complex datasets of today's life science research. In this concise textbook, the authors' fresh pedagogical approaches lead biology students from first principles towards computational thinking. A team of renowned bioinformaticians take innovative routes to introduce computational ideas in the context of real biological problems. Intuitive explanations promote deep understanding, using little mathematical formalism. Self-contained chapters show how computational procedures are developed and applied to central topics in bioinformatics and genomics, such as the genetic basis of disease, genome evolution or the tree of life concept. Using bioinformatic resources requires a basic understanding of what bioinformatics is and what it can do. Rather than just presenting tools, the authors - each a leading scientist - engage the students' problem-solving skills, preparing them to meet the computational challenges of their life science careers.

Computing for Comparative Microbial Genomics

Bioinformatics for Microbiologists

Author: David Wayne Ussery,Trudy M. Wassenaar,Stefano Borini

Publisher: Springer Science & Business Media

ISBN: 1848002548

Category: Science

Page: 270

View: 3787

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Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes. It is a long road from molecular biology to systems biology, and in a sense this text can be thought of as a path bridging these ? elds. The goal of this book is to p- vide a coherent set of tools and a methodological framework for starting with raw DNA sequences and producing fully annotated genome sequences, and then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Organization and Features The text is divided into four main parts: Introduction, Comparative Genomics, Transcriptomics and Proteomics, and ? nally Microbial Communities. The ? rst ? ve chapters are introductions of various sorts. Each of these chapters represents an introduction to a speci? c scienti? c ? eld, to bring all readers up to the same basic level before proceeding on to the methods of comparing genomes. First, a brief overview of molecular biology and of the concept of sequences as biological inf- mation are given.

Bioinformatics

Concepts, Methodologies, Tools, and Applications

Author: Information Resources Management Association

Publisher: IGI Global

ISBN: 146663605X

Category: Computers

Page: 1246

View: 2815

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"Bioinformatics: Concepts, Methodologies, Tools, and Applications highlights the area of bioinformatics and its impact over the medical community with its innovations that change how we recognize and care for illnesses"--Provided by publisher.

Bioinformatics

A Practical Guide to the Analysis of Genes and Proteins

Author: Andreas D. Baxevanis,B. F. Francis Ouellette

Publisher: Wiley-Interscience

ISBN: N.A

Category: Computers

Page: 540

View: 2858

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This book provides readers with a practical guide covering the full scope of key concepts in bioinformatics, from databases to predictive and comparative algorithms.

Animal Behavior: Das Original mit Übersetzungshilfen. Easy Reading Edition

An Evolutionary Approach

Author: John Alcock

Publisher: Spektrum Akademischer Verlag

ISBN: 9783827417831

Category: Science

Page: 580

View: 1452

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John Alcocks Standardwerk Animal Behavior - jetzt in Form eines völlig neuen Lehrbuchtyps, der speziell für die Studiensituation im deutschsprachigen Raum konzipiert wurde.* Das erfolgreiche Lehrbuch Animal Behavior stellt die verschiedenen Aspekte tierischen Verhaltens in einen evolutionsbiologischen Rahmen. Es behandelt die grundlegenden Mechanismen des Verhaltens ebenso wie seine stammesgeschichtlichen Ursachen und betont die Bedeutung der Evolutionstheorie als einigendes Element der unterschiedlichen Teildisziplinen der Verhaltensbiologie. Wichtige Konzepte werden sowohl an Wirbellosen wie an Wirbeltieren verdeutlicht. Alcocks klarer und engagierter Schreibstil macht es auch Anfängern trotz der stark konzeptionellen Ausrichtung des Werkes leicht, den Stoff zu verstehen. Die nun vorliegende achte Auflage des Standardwerkes wurde völlig neu geschrieben. Zahlreiche Erkenntnisse aus jüngster Zeit haben darin Eingang gefunden. Verständnisfragen direkt an den entsprechenden Textstellen regen dazu an, sich mit dem gerade gelesenen Stoff auseinanderzusetzen. Die beiden Kapitel über die Einflüsse von Vererbung und Umwelt auf die Entwicklung wurden vereint, um zu verdeutlichen, dass Entwicklungsprozesse sowohl von genetischen als auch von Umweltfaktoren abhängen. Der Autor führt dem Leser immer wieder vor Augen, welche Rolle der Überprüfung von Theorien und Hypothesen zukommt und dass wissenschaftliche Schlussfolgerungen immer nur vorübergehend gültig sind. So werden in diesem Buch auch kontrovers diskutierte und bisher ungelöste Probleme angesprochen. * Von Studierenden der Biowissenschaften wird heute erwartet, dass sie im Laufe ihres Studiums englische Literatur problemlos lesen und verstehen und schließlich auch Forschungsergebnisse auf Englisch kommunizieren können. Den Weg dorthin bereitet der neu entwickelte Lehrbuchtyp Easy Reading - Das Original mit Übersetzungshilfen. So bietet die vorliegende Ausgabe von Animal Behavior in einem zusammen: den englischen Originaltext deutsche Übersetzungshilfen in der Randspalte deutschsprachige Verständnisfragen / Übungsaufgaben ein englisch-deutsches Glossar deutsch- und englischsprachige Kapitelzusammenfassungen und auf der Website www.elsevier.de/alcock: eine Übersicht über die im Buch erwähnten Arten (deutsch, englisch, lateinisch) Internetlinks für Deutschland, Österreich und die Schweiz Wesentlicher Zusatznutzen der "Easy Reading"-Ausgabe ist, das Lesen des englischen Grundtextes zu erleichtern und in die spezielle wissenschaftliche Terminologie einzuführen. Wer dieses Buch durcharbeitet, steigert somit seine fachliche und seine sprachliche Kompetenz zugleich. This new edition of Animal Behavior has been completely rewritten with coverage of much recent work in animal behavior, resulting in a thoroughly up-to-date text. Notable is the inclusion, for the first time, of discussion questions embedded in the text itself, rather than appended to the end of each chapter. This format is designed to encourage students to reflect on the material they have just digested while also making it easier for instructors to promote a problem-solving approach to the subject in their classes. Another key organizational improvement is the consolidation of what had been two separate chapters on the genetic and environmental influences on development. By combining this material, the new Chapter 3 makes a stronger, more tightly argued case for the view that development is a truly interactive process codependent on both genetic and environmental factors. Like previous editions, the book shows how evolutionary biologists analyze all aspects of behavior. It is distinguished by its balanced treatment of both the underlying mechanisms and evolutionary causes of behavior, and stresses the utility of evolutionary theory in unifying the different behavio

Bioinformatics in the Post-genomic Era

The Role of Biophysics

Author: Ivan Y. Torshin

Publisher: Nova Publishers

ISBN: 9781600210488

Category: Science

Page: 255

View: 1078

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Biomedicine is one of the most important fields for the prospective applications of the information from human genome studies. However, there are many 'white spots' in the present-day understanding of the biomedical implications of this information. Given that at least half of the proteins in the established sequence of the human genome have no annotation whatsoever and that the sequence similarity searches are not likely to produce any, definite research strategies to analyse the functions of these unknown proteins as well as other enigmatic aspects of the human genome are being elaborated. The elaboration of the logistics of these research strategies, of the relevant computational methodologies as well as the general management of the informational complexity of the biological systems belong to the main tasks for the post-genomic bioinformatics. This volume concentrates on the role of the biophysical studies and biophysical concepts that can assist the endeavour.

Basic Concepts of Molecular Pathology

Author: Philip T. Cagle,Timothy Craig Allen

Publisher: Springer Science & Business Media

ISBN: 9780387896267

Category: Medical

Page: 190

View: 5864

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Over the past two decades there has been an explosion in knowledge about the molecular pathology of human diseases which accelerated with the sequencing of the human genome in 2003. Molecular diagnostics and molecular targeted therapy have contributed to the current concept of personalized patient care that is now routine in many medical centers. As a result, general and subspecialty pathologists, clinical practitioners of all types and radiologists must now have an understanding of the basic concepts of molecular pathology and their role in new diagnostic and therapeutic applications to patient care. The Molecular Pathology Library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. Basic Concepts of Molecular Pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the understanding, diagnosis and treatment of human diseases in the age of personalized medicine. Those medical practitioners, residents, fellows and students who need to refer to the terminology and concepts of molecular pathology in their patient care will find the Basic Concepts of Molecular Pathology to be a succinct, portable, user-friendly aid in their practice and studies. The service-based physician will find this handy reference to be valuable at the laboratory benchside, at the patient bedside, at multidisciplinary patient care conferences or as a review for examinations.

Bioinformatics for Geneticists

A Bioinformatics Primer for the Analysis of Genetic Data

Author: Michael R. Barnes

Publisher: John Wiley & Sons

ISBN: 0470026197

Category: Computers

Page: 554

View: 1248

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Bioinformatics for geneticists describes the key bioinformatics and genetic analysis processes that are needed to identify human genetic determinants. Including SNP functional analysis and statistical genetics.

Bioinformatics: Genomics and Proteomics

Author: Ruchi Singh

Publisher: Vikas Publishing House

ISBN: 9325978555

Category: Technology & Engineering

Page: N.A

View: 2734

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This is an innovative textbook for undergraduates as well as postgraduates offering basic knowledge of biology. Its aim is to provide state-of-the-art information about this developing science that has the potential to replace existing biological approaches to study genes and proteins. The chapters are explained in a concise yet detailed manner, including ample cross-references, references to literature and databases, tables and illustrations. The book's sound approach to this intricately complex field makes it an exceptional resource for further exploration into biochemistry, molecular biology, genomics and drug designing fields. Abundant learning features make this book the ideal teaching and learning tool. KEY FEATURES • Illustrations to bolster understanding of complex biochemical relations • Tables for quick access to precise data • Extensive end-of-chapter exercises and references • The most basic details furnished for those who are new to biology • User-friendly, Internet-based bioinformatics tools that allow researchers to extract information from databases and analyze it • Analysis of one software tool discussed in each chapter step-by-step from entering the input till interpretation of the results This is an in-depth textbook written for the biologist who wants a thorough understanding of the popular bioinformatics programs and molecular databases currently in use. It provides a broad, application-oriented overview of this technology.