Advances in Psychiatry

Author: Afzal Javed,Kostas N. Fountoulakis

Publisher: Springer

ISBN: 3319705547

Category: Medical

Page: 740

View: 3167

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This book will be the newest edition on the series ‘advances in psychiatry’. The previous 3 volumes can be found online at http://www.wpanet.org/detail.php?section_id=10&content_id=660 . They were highly successful in covering a broad area of psychiatry from different perspectives and angles and by reflecting both specialized but also international and global approaches. This series have guaranteed quality therefore can be used by different scientific groups for teaching and learning and also as a means for fast dissemination of advanced research and transformation of research findings into the everyday clinical practice. There is already a body of readers anticipating the next volume.

Advances in Psychodynamic Psychiatry

Author: César A. Alfonso,Richard C. Friedman,Jennifer I. Downey

Publisher: Guilford Press

ISBN: 9781462538638

Category: Psychology

Page: 356

View: 4281

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Bringing together important articles from Psychodynamic Psychiatry, this volume shows how contemporary practitioners are using a multidimensional biopsychosocial approach to increase the robustness of clinical research and the effectiveness of patient care. Chapters review cutting-edge approaches to formulating anxiety and mood disorders, eating disorders, traumatic grief, substance use and addictive behaviors, obsessive–compulsive disorder, personality disorders, schizophrenia, somatic symptom disorders, and trauma and stressor-related disorders. Treatment of specific populations is addressed, including infants and parents, children, spouses of the chronically ill, survivors of intimate partner violence, criminal offenders, and the elderly. Featuring rich case illustrations, the book integrates psychoanalytic concepts with advances in knowledge about neuroscience, gene–environment interactions, and the physiological impact of adversity.

Advances in Psychiatry

Author: Chittaranjan Andrade

Publisher: Oxford University Press, USA

ISBN: N.A

Category: Architecture

Page: 288

View: 7744

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This book aims to provide readers with a theoretical and practical update on the advances in psychiatry.

Proteomics and Metabolomics in Psychiatry

Author: D. Martins-de-Souza

Publisher: Karger Medical and Scientific Publishers

ISBN: 331802600X

Category: Science

Page: 150

View: 7242

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This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections – Schizophrenia/Psychotic Disorders and Mood Disorders – deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.

Advances in Biological Psychiatry

Author: Jaak Panksepp

Publisher: Elsevier

ISBN: 0762301708

Category: Medical

Page: 236

View: 6803

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This series aims to update major areas of biological psychiatry and summarize important research conducted since the 1980s. It also highlights recent approaches that allow researchers to quantify normal and abnormal brain functions at a high level of precision.

Developments in Psychiatry in India

Clinical, Research and Policy Perspectives

Author: Savita Malhotra,Subho Chakrabarti

Publisher: Springer

ISBN: 8132216741

Category: Medical

Page: 636

View: 5464

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The volume evaluates major developments in psychiatry in India from the 1950s, and highlights the areas where Indian psychiatry has contributed to the development of the subject worldwide. The chapters review international as well as Indian developments in psychiatry and its sub-specialities. A wide range of clinical, research and policy-related topics have been covered in the volume, which begins with an overview of the history of psychiatry in India, moving on to developments in various sub-specialities of psychiatry in the last 60 years or so. It then specifically discusses developments in psychology and psychodynamics, general adult and child psychiatry, substance use psychiatry, community psychiatry, liaison psychiatry, and other psychiatric sub-specialities. Developments in treatment, the status of training and service in psychiatry and legal issues related to the practice of psychiatry in India are also included. The contributors to this volume are nationally and internationally recognized experts in different areas of psychiatry. Most of them have had some association, or are currently associated, with the Department of Psychiatry at the Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Epigenetics in Psychiatry

Author: Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos

Publisher: Elsevier

ISBN: 0124171346

Category: Science

Page: 664

View: 7511

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Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery

Neuroprogression in Psychiatric Disorders

Author: A. Halaris,B.E. Leonard

Publisher: Karger Medical and Scientific Publishers

ISBN: 3318060518

Category: Medical

Page: 182

View: 5554

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In this volume, international experts critically review cutting-edge advances in neuroprogression research. The relevance of these findings to psychiatric and neurological disorders is clarified. Potential etiopathological mechanisms of neuroprogression are described in detail. Special emphasis is placed on the role of the immune system in stress and stress-related disorders and brain-immune interactions. The epigenetic consequences of adverse experiences in early childhood, which may prelude major psychiatric disorders, are also considered. Recent research has not only provided evidence of neuroprogression in psychiatric and neurological disorders, but has shown that pharmacologic interventions have the potential to arrest this process. Advances in testing and imaging will lead to timely diagnosis and earlier treatment. Identification of neurological mechanisms alongside (epi-)genetic vulnerability markers will create truly personalized treatment programs. This book is a valuable resource for everyone who wishes to gain insight into the essential features of the neuroprogressive course of major psychiatric and neurological disorders. In particular, psychiatrists, neuroscientists and neurologists ¬ as well as immunologists, pharmacologists and molecular biologists - will find very informative chapters of direct relevance to their field.

Research Advances in Genetics and Genomics

Implications for Psychiatry

Author: Nancy C. Andreasen

Publisher: American Psychiatric Pub

ISBN: 9781585627103

Category: Medical

Page: 160

View: 7198

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Research Advances in Genetics and Genomics: Implications for Psychiatry introduces mental health professionals to exciting breakthroughs in endophenotypes, animal models, microarrays, and genetic mapping, as well as general strategies for identifying the genetic mechanisms of mental illnesses. Uniquely valuable both as summary and signpost, this concise volume provides a fascinating overview of recent cutting-edge developments in the application of molecular genetics, genomics, and proteomics to the study of psychiatric populations. By reading Research Advances in Genetics and Genomics, you will gain a better understanding of Psychiatric Genetics -- Reviews and assesses the major research paradigms that have emerged in the field of psychiatric genetics over the several past decades, exploring the major conceptual and philosophical issues they pose and the value of their integration. Molecular Structure of Nucleic Acids -- An overview of the double-helix discovery and provides a context for current endeavors, the original one-page April 1953 Nature paper by Watson and Crick, which sparked a revolution in the life sciences. Psychiatry in the Genomics Era -- Posits that one of the most important consequences of genomics will be the development of individualized treatments that allow a clinician to tailor therapy on the basis of the unique genotype of each patient rather than on the mean responses of groups of unrelated patients. The Genomics Revolution -- Details the implications of the genome for future medical practice, including the potential for developing methods and tools to better understand, treat, and prevent major mental disorders. The Endophenotype Concept in Psychiatry -- Explains the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics, such as schizophrenia. The Genes and Brains of Mice and Men -- Shows why a detailed assessment of brain function in mice is so important for advancing psychiatric research in humans. Humans and mice share numerous features-in fact, for an estimated 99% of human genes a mouse version may be identified-of brain organization and behavioral responses to many pharmacological agents. Microarray Technology -- Asserts that microarrays present a methodology for identifying genes or pathways for new and unique potential drug targets, determining premorbid diagnosis, predicting drug responsiveness for individual patients, and, eventually, initiating gene therapy and prevention strategies. Meticulously referenced, this volume is exceptionally useful as a starting point for understanding the impact of genetics and genomics on psychiatry, serving to introduce psychiatrists, psychologists, neurologists, and geneticists to this exciting field.

Brain Circuitry and Signaling in Psychiatry

Basic Science and Clinical Implications

Author: Gary B. Kaplan,Ronald P. Hammer

Publisher: American Psychiatric Pub

ISBN: 9781585627714

Category: Medical

Page: 284

View: 1170

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The 1990s, appropriately termed "the decade of the brain," witnessed unprecedented advances in our knowledge of psychiatric neuroscience. Yet with every advance, we realized afresh that we were still in the beginning stages of a much longer journey. This text chronicles the next step of that journey. Structured around a proven teaching methodology that uniquely integrates the clinical aspects of psychiatric disorders with their neurobiology, this volume begins with two introductory chapters on functional neural circuitry and neural signaling pathways. The remaining six chapters present current knowledge on the neuroanatomic and neurochemical mechanisms underlying schizophrenia, addiction, anxiety, depression, bipolar disorder, and dementia/Alzheimer's disease. For clarity and consistency, each chapter features the same four divisions -- clinical presentation, neural circuitry, signaling pathways, and psychopharmacology -- as they relate to Schizophrenia, which reviews studies of the neural basis of schizophrenia and describes how the cortex, the thalamus, the basal ganglia, and the medial temporal lobe work together during normal brain function and then how each is perturbed in psychosis. Addiction, which focuses on the consequences of psychoactive substance use, including compulsive practices (e.g., eating, sex, Internet browsing) that might also involve the same brain circuits and signaling pathways. Of exceptional value are two unique illustrations that capture -- for the first time -- much of what we know about the anatomy and neurochemistry underlying the behavioral symptoms of addiction. Anxiety, which presents current hypotheses regarding neurocircuitry and signaling pathways for the three best-studied (from a neurobiologic perspective) anxiety disorders: panic disorder, posttraumatic stress disorder, and obsessive-compulsive disorder. Depression, which offers evidence for the involvement of highly interconnected cortical and limbic structures such as the prefrontal cortex, medial thalamus, amygdala, ventral striatum, hippocampus, and the hypothalamic-pituitary-adrenal axis in unipolar major depression, and suggests target areas (such as the cAMP pathway) for study in the development of new antidepressants. Bipolar disorder, which shows that specific abnormalities in signal transduction pathways, including protein kinase activity, G protein levels, and gene expression, are unique to bipolar patients, concluding that the actions of lithium and anticonvulsants on intracellular signaling pathways provide a new paradigm for novel pharmacological interventions. Dementia and Alzheimer's disease, which details current findings on neurofibrillary degeneration, relevant genes and proteins, pathogenesis (metabolic decline, defective cell repair, and Aß toxicity), and treatment strategies (neurotransmitter replacement, and neuroprotective and regenerative approaches). Discusses frontotemporal dementia, dementia with Lewy bodies, Parkinson's disease, and vascular dementia. Meticulously researched and clearly written by 15 contributors -- all recognized experts from leading research and teaching institutions in the United States -- this compact and extensively illustrated volume stands out in the literature because it combines readability and practicality with the breadth and depth typically found only in far lengthier works. Psychiatric practitioners, residents, and students alike will welcome this informative, easy-to-read text, which will also be of special interest to mental health and pharmaceutical industry professionals, and of general interest to anyone who wants to know more about the biology of psychiatric illness.

Advances in Brain Imaging

Author: John M. Morihisa

Publisher: American Psychiatric Pub

ISBN: 9781585628001

Category: Medical

Page: 204

View: 9184

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Brain imaging and its application to major psychiatric disorders such as depression, obsessive-compulsive disorder (OCD), and schizophrenia is one of the most exciting fields in psychiatry today. This thought-provoking collection details the work of five scientists who report some of the most recent findings in the field, review the relevant data in the literature, and place this research within a critical neuroscience context. Each chapter tells a fascinating story: Chapter 1, Functional Brain Imaging in Psychiatry: The Next Wave, reviews the strengths and limitations of functional magnetic resonance imaging (fMRI), emphasizes the therapeutic implications of brain imaging findings, and suggests that this field may achieve its greatest utility in the search for the genetic bases for psychiatric disorders such as schizophrenia. Chapter 2, Cognitive Neuroscience: The New Neuroscience of the Mind and Its Implications for Psychiatry, emphasizes the importance of cognitive deficits in our understanding of psychiatric disorders such as schizophrenia and OCD, presenting an exciting discussion of the development of a theory of altered executive function. Chapter 3, Functional Magnetic Resonance Imaging in Children and Adolescents: Implications for Research on Emotion, explains a compelling new way of using fMRI to investigate disorders of emotion (such as major depression, generalized anxiety disorder, separation anxiety disorder, and social phobia) in children, synthesizing neuroscience, psychiatry, and developmental psychology. Chapter 4, Brain Structure and Function in Late-Life Depression, presents both structural and functional brain imaging findings, such as decreased brain volume and abnormalities of regional cerebral blood flow, in patients with late-life depression, examining how they compare with younger patients with major depression and raising an intriguing question of trait versus state as the cause for some of these abnormalities. Chapter 5, Neuroimaging Studies of Major Depression, details a distinctive longitudinal and intensely multimodal neuroscience approach particularly well suited for brain studies, describing not only the abnormalities, but also the changes in these abnormalities after therapeutic intervention, showing that some appear to depend on the patient's mood and that other neurophysiologic differences persist even after treatment. The provocative research breakthroughs and findings presented in this volume may lead to important insights in diagnosis, treatment response, and prognosis for some of today's most challenging psychiatric disorders. Researchers and clinicians alike will find that this remarkable volume enhances their understanding of the theory and practice of brain imaging in psychiatry and offers an exciting glimpse of the future directions of both the technology and the science.

Overdiagnosis in Psychiatry

How Modern Psychiatry Lost Its Way While Creating a Diagnosis for Almost All of Life's Misfortunes

Author: Joel Paris

Publisher: Oxford University Press

ISBN: 0199350655

Category: Medical

Page: 272

View: 9492

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Dr. Joel Paris's Overdiagnosis in Psychiatry takes a much-needed look at the dangerous epidemic of unnecessary or incorrect treatments. The last 30 years of psychiatry have seen the development of a system of classification aimed at establishing greater scientific credibility. Unfortunately, the current categories are based entirely on signs and symptoms rather than on causes, which remain unknown. This has inevitably made diagnosis imprecise and uncertain. The result is that well-meaning professionals can have problems separating psychopathology from normality, can be unduly influenced by diagnostic fads, and can ultimately wind up prescribing treatments that do more harm than good. Paris examines prominent examples of overused diagnoses including major depressive disorder, ADHD, bipolar-II disorder, autism spectrum disorders, and PTSD.

Recent Advances in Biological Psychiatry

The Proceedings of the Twenty-Second Annual Convention and Scientific Program of the Society of Biological Psychiatry, Detroit, Michigan, May 5–7, 1967

Author: Joseph Wortis

Publisher: Springer Science & Business Media

ISBN: 1468490729

Category: Medical

Page: 328

View: 9125

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A method of behavioral control which utilizes nutritive sucking as the operant has been evolved in our laboratory. Using this technique we studied the role of arousal and learning in the development of environ mental control over earliest feeding behavior. Few of the infants in our studies were able to coordinate their sucking behavior to arbitrary operant-discrimination schedules, but when the individual pattern of suck ing was taken into consideration, some infants rapidly adapted to the reinforcement schedule. Data from various reinforcement schedules suggest that earliest mothering involves a mutual adaptation in which the nurturing environment approximates and then entrains the infant's feeding behavior by a perceptive manipulation of the infant's state of arousal. Coordination between the infant and its environment sets the stage for associative learning, which develops following maturation of the infant's discriminative and response capacities. The process of behavioral acquisition begins with unconditioned feeding responses, which are transformed into complex learned behavior through the mediation of an appropriately reinforcing environment. The infants studied showed individual differences in susceptibility to environmental control and in response to frustration. The relative importance of arousal and learning as determinants of infant behavior are discussed and a hypothetical model for the earliest mother-infant relationship is proposed.

Advances in the Neurobiology of Schizophrenia

Author: Johan A. den Boer,H. G. M. Westenberg,Herman M. Van Praag

Publisher: Wiley

ISBN: 9780471952879

Category: Psychology

Page: 482

View: 6629

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Internationally renowned experts in schizophrenia present an up-to-date review of this disorder's biological rather than psychological origins. Surveys new drugs for its treatment which are directed at novel biochemical targets in the brain. Includes a clinical profile of newly available therapeutic agents.

Advances in Old Age Psychiatry

Chromosomes to Community Care

Author: Clive Holmes,Robert Howard

Publisher: Wrightson Biomedical Pub Limited

ISBN: N.A

Category: Medical

Page: 284

View: 1065

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Arrangement of 22 chapters is in five sections, the first three of which are devoted to the dementias and cover genetic and neurochemical risk factors, clinical and pathological features of Alzheimer's disease, cortical Lewy body disease, frontal lobe and vascular dementia, and pharmacological, behavioral, and environmental treatment strategies. Section four deals with the treatment and prognosis of dysthymia and depressive illness, and the final section looks at cross-cultural issues and functional disorders. Distributed by Taylor and Francis. Annotation copyrighted by Book News, Inc., Portland, OR